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- Title
Hypertonic saccharide solution delays pyroptosis in murine macrophages regardless of the membrane binding of gasdermin D N‐terminal.
- Authors
Zheng, Jiashuo; Wang, Dingyu; Chen, Qianyue; Liu, Qiyao; Lin, Zhaoyu; Hu, Qiongyuan; Wu, Xiuwen; Gao, Xiang; Li, Qiurong; Ren, Jianan
- Abstract
Pyroptosis is a type of programmed lytic cell death that could be activated by either the canonical or noncanonical inflammasome pathway. In this study, we aimed to examine the effect of hypertonic solution on noncanonical pyroptosis in macrophage. We found that although hypertonic solution had a general inhibitory effect on noncanonical pyroptosis, the underlying mechanism varied by the solute causing hypertonicity. Specifically, hypertonic NaCl or KCl solution inhibited the cleavage of gasdermin D, the pore‐forming protein in pyroptosis, whereas hypertonic saccharide solution did not affect the cleavage or membrane binding of gasdermin D. In this case, nevertheless, pyroptosis was still inhibited as evidenced by the preserved mitochondria activity and cell membrane permeability.
- Subjects
HYPERTONIC solutions; APOPTOSIS; CELL permeability; MEMBRANE permeability (Biology); CELL membranes
- Publication
European Journal of Immunology, 2020, Vol 50, Issue 3, p464
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.201948230