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- Title
Lipid Peroxidation and Transforming Growth Factor-β1 Levels in Gastric Cancer at Pathologic Stages.
- Authors
Tüzün, Sefa; Yücel, Ahmet Fikret; Pergel, Ahmet; Kemik, Ahu Sarbay; Kermik, Özgür
- Abstract
Objective: High levels of TGF-β1 and enhanced TGF-β1 receptor signaling are related to the pathology of gastric cancer. This effect is caused by oxidative stress and lipid peroxidation products. The aim of this study was to investigate the levels of TGF-β1 and lipid peroxidation products in gastric cancerpatients and their correlation with pathologic stage.Material and Methods: Lipid peroxidation products and TGF-β1 levels were studied in the serum samples of 50 gastric cancer patients and 18 controlsubjects.Results: HNE-protein adducts and TGF-β1 levels were significantly higher in T2, T3 and T4 gastric cancers than in either the T1 stage or controls(p<0.001). Pathologic stage was correlated with TGF-β1 levels (r=0.702, p<0.05).Conclusion: These markers production may contribute to tumor angiogenesis and aid in the prognosis of the gastric cancer.
- Subjects
TURKEY; STATISTICAL correlation; GROWTH factors; LIPID peroxidation (Biology); STATISTICS; STOMACH tumors; TUMOR classification; U-statistics; DATA analysis
- Publication
Balkan Medical Journal, 2012, Vol 29, Issue 3, p273
- ISSN
2146-3123
- Publication type
Article
- DOI
10.5152/balkanmedj.2012.026