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- Title
Role of the MCT-1 T1470A polymorphism (rs1049434) in the Uptake of Lactate in Resistance Trained Females.
- Authors
Hawkins, William C.; Branon, Lauren M.; Bailey, Rhiannon K.; Schafer, Conner J.; Delaney, Kimberly J.
- Abstract
The purpose of this investigation was to examine the role of the MCT-1 T1470A single nucleotide polymorphism on blood lactate clearance rates in resistance trained females. Twenty-seven resistance trained females participated in our investigation. Each participant performed a thirty second Wingate test on a cycle ergometer. Lactate was measured before the test, immediately following the test and -10, -20, -30 and -40 minutes post. Lactate decreases were calculated for each 10-minute period. Participants were divided into three groups based on their T1470A genotype (TT, TA, AA). There was no significant interaction between genotype and lactate clearance (p > 0.05), however the TT genotype group had significantly higher clearance rates when collapsed across time points (p ≤ 0.05). Lactate clearance was higher in the TT genotype when compared to both the TA genotype (p < 0.05) and the AA genotype (p < 0.05). This effect was caused by significantly higher lactate accumulation in TT genotype subjects immediately following the Wingate test when compared to TA (p < 0.05) and AA (p < 0.05) subjects. To our knowledge, our investigation is the first that demonstrates that the MCT-1 genotype effects lactate clearance in women. Our findings differ from the body of literature carried out using male participants, which suggests that the T allele adversely effects lactate clearance. Further, our findings indicate that peak lactate clearance occurs earlier in the TT group compared to the TA and AA group in resistance trained females. Future research should continue to examine the MCT-1 polymorphism in women and how this genetic information can be integrated into exercise prescription protocols.
- Subjects
RESISTANCE training; SINGLE nucleotide polymorphisms; BLOOD lactate; LACTATES
- Publication
Kentucky SHAPE JOURNAL, 2020, Vol 57, Issue 2, p56
- ISSN
1071-2577
- Publication type
Article