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- Title
Cognitive complaints and cognitive impairment following BEP chemotherapy in patients with testicular cancer.
- Authors
Schagen, Sanne B.; Boogerd, Willem; Muller, Martin J.; Huinink, Wim Ten Bokkel; Moonen, Luc; Meinhardt, Wim; Van Dam, Frits S. A. M.
- Abstract
Introduction. There is growing concern that some cytotoxic regimens for cancer affect cognitive functioning. This study examined the prevalence of cognitive complaints and deficits in testicular cancer (TC) patients treated with the worldwide standard BEP (bleomycin, etoposide and cisplatin) chemotherapy. Materials and methods. Seventy TC patients treated with BEP chemotherapy after surgery (S+CT) were examined with interviews and neuropsychological tests. These patients were compared with 57 TC patients treated with radiotherapy after surgery (S+RT) and with 55 TC patients that received surgery only (S). Patients were examined a median of 3 years after completion of treatment. Results. Thirty two percent of the S+CT patients reported cognitive complaints compared with 32% of the S+RT patients and 27% of the S patients (p=0.85). No differences in mean cognitive test performance were observed between the groups. On individual impairment scores, more S+CT patients showed cognitive dysfunction compared with S patients, but not compared with S+RT patients (S+CT versus S [p=0.038, OR=4.6, CI=1.1-19.7], S+CT versus S+RT [p=0.70, OR=0.8, CI=0.3-2.4] and S+RT versus S [p=0.070, OR=3.7, CI=0.8-15.7). Cognitive complaints were not related to cognitive test performance, but to emotional distress and fatigue. Discussion. Cognitive complaints are common among TC patients, independent of treatment modality. These complaints are related to emotional distress and fatigue and not to formal cognitive deficits. The finding of a small group of TC patients treated with chemotherapy exhibiting cognitive deficits should be confirmed in a prospective study before we can decide on its cause and relevance.
- Subjects
COGNITION disorders; COGNITIVE ability; CANCER patients; BLEOMYCIN; ETOPOSIDE; CISPLATIN; ANTINEOPLASTIC antibiotics; DRUG therapy
- Publication
Acta Oncologica, 2008, Vol 47, Issue 1, p63
- ISSN
0284-186X
- Publication type
Article
- DOI
10.1080/02841860701518058