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- Title
Impact of persistent bovine viral diarrhea virus infection on indicators of innate and adaptive immune function in holstein calves and cows.
- Authors
Gomes, Viviani; Sobreira Basqueira, Natália; Nascimento da Silva, Karen; Pituco, Edviges Maristela; Pacito, Sara Altissimo; Hurley, David John
- Abstract
We evaluated some indicators of innate and humoral immune response in persistently infected (PI) Holstein calves and cows from 1 to 36 months of age matched with controls from the same herd. The effects were cataloged by grouping animals into the following age groups: <12 months, 13 to 24 months, and 25 to 36 months of age. Blood samples were collected once from each animal to measure total serum protein, haptoglobin, and neutralizing antibodies titers induced by respiratory virus vaccination. Total serum protein (g/dL) was lowest in PI calves younger until 24 months old, while haptoglobin concentration was higher in PI cattle. The serum neutralizing titers against BVDV and BRSV were lower in all PI calves and cattle than in controls. PI cattle have a high serum concentration of haptoglobin, and its possible dysregulated innate immune response appears to impact the efficacy of their adaptative immune responses, resulting in poor vaccine responsiveness.
- Subjects
BOVINE viral diarrhea; BOVINE viral diarrhea virus; BLOOD proteins; CALVES; ANTIBODY titer; VIRUS diseases; HUMORAL immunity; COWS; VIRAL antibodies
- Publication
Ciência Rural, 2023, Vol 53, Issue 5, p1
- ISSN
0103-8478
- Publication type
Article
- DOI
10.1590/0103-8478cr20210819