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- Title
A prospective multicenter cohort study for the evaluation of long-term disabilities among critical care survivors of sepsis in Brazil.
- Authors
Teixeira, Cassiano; Schneider, Daniel; Kochhann, Renata; Jeffman, Rodrigo; Dutra, Francine; Sganzerla, Daniel; Mariani, Debora; Rosa, Regis Goulart
- Abstract
Objective: To evaluate the prevalence of long-term physical, mental and cognitive disabilities among ICU survivors of sepsis in Brazil. Methods: A prospective cohort study was conducted in 10 Brazilian ICUs. Adult post-ICU survivors with severe sepsis/septic shock, and with an ICU stay >72h were followed for 12 months. The outcomes were physical dependence at 3 months; anxiety, depression and posttraumatic stress disorder (PTSD) at 6 months, and cognitive dysfunction at 12 months. Results: In total, 417 survivors of sepsis were followed. The prevalence of physical dependence, anxiety, depression, PTSD and cognitive dysfunction were 42.2%, 17.6%, 17.6%, 14.8% and 70%, respectively. No higher education (PR, 1.52; 95% CI, 1.04-2.22) and previous physical dependence (PR, 2.59; 95%CI, 2.05-3.28) were associated with physical dependence. Depression symptoms at ICU discharge (PR, 2.32; 95%CI, 1.27-4.22) was associated with anxiety. Previous diagnosis of depression (PR, 2.22; 95%CI, 1.06-4.65), depression symptoms at ICU discharge (PR, 2.22; 95%CI, 1.06-4.65) and decrease in functional status (PR, 2.34; 95%CI, 1.03-5.30) were associated with depression. Decrease in functional status (PR, 3.86, 95%CI, 1.32-11.30) was associated with PTSD. Age .65 years (PR, 1.35; 95%CI, 1.10-1.66) was associated cognitive dysfunction. Conclusion: The network of potential risk factors for long-term sepsis-related disabilities is complex and involves factors of multiple domains.
- Subjects
INTENSIVE care units; POST-traumatic stress disorder
- Publication
Revista Brasileira de Terapia Intensiva, 2018, Vol 30, pS4
- ISSN
0103-507X
- Publication type
Article