We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Circulating anti-Müllerian hormone levels in relation to nutritional status and selected adipokines levels in polycystic ovary syndrome.
- Authors
Olszanecka‐Glinianowicz, Magdalena; Madej, Paweł; Owczarek, Aleksander; Chudek, Jerzy; Skałba, Piotr
- Abstract
Objective The aim of the study was to analyse the relationship between nutritional status, selected adipokines and plasma anti-Müllerian hormone ( AMH) levels in women with polycystic ovary syndrome ( PCOS). Study Design Patients and Measurements A prospective, cross-sectional study, involving 87 PCOS (48 obese) women and 67 non- PCOS women (36 obese). Anthropometric parameters were measured, and body composition was determined by the bioimpedance method. Fasting serum glucose, androgens, FSH, LH, SHBG, insulin, AMH, apelin-36, adiponectin, leptin and omentin-1 were measured. Results Plasma AMH levels were significantly higher in PCOS compared to the non- PCOS group (7·8 ± 4·3 ng/ml vs 4·4 ± 2·4 ng/ml; P < 0·001). Furthermore, AMH levels were higher in both PCOS and non- PCOS normal weight than in obese subgroups (8·9 ± 4·4 ng/ml vs 7·0 ± 4·0 ng/ml; P < 0·05 and 5·1 ± 2·4 ng/ml vs 3·9 ± 2·3 ng/ml; P < 0·05). There were negative correlations between AMH levels and anthropometric parameters (body mass, BMI, fat mass and percentage, as well as waist circumference) and plasma omentin-1 concentrations ( R = −0·28, P < 0·001; R = −0·30, P < 0·001; R = −0·36, P < 0·001; R = −0·34, P < 0·001; R = −0·23, P < 0·01; and R = −0·20, P < 0·05, respectively) in all study groups. In multiple regression analysis, circulating AMH level variability was explained by omentin-1 levels and anthropometric parameters (excluding waist circumference). Conclusions In this observational study, nutritional status appears to be the main factor influencing circulating AMH levels independent of PCOS. The observed AMH association with omentin-1 levels suggests that this adipokine may be a link between hormonal dysfunction of adipose tissue related to obesity and decreased AMH secretion.
- Subjects
ADIPOKINES; POLYCYSTIC ovary syndrome; ANTHROPOMETRY; ADIPONECTIN; BODY composition; BODY mass index
- Publication
Clinical Endocrinology, 2015, Vol 83, Issue 1, p98
- ISSN
0300-0664
- Publication type
Article
- DOI
10.1111/cen.12687