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- Title
Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference.
- Authors
Sze, Alexandre; Olagnier, David; Hadj, Samar Bel; Xiaoying Han; Xiao Hong Tian; Hong-Tao Xu; Long Yang; Qingwen Shi; Penghua Wang; Wainberg, Mark A.; Jian Hui Wu; Rongtuan Lin
- Abstract
Flaviviruses including Zika, Dengue and Hepatitis C virus cause debilitating diseases in humans, and the former are emerging as global health concerns with no antiviral treatments. We investigated Sophora Flavecens, used in Chinese medicine, as a source for antiviral compounds. We isolated Sophoraflavenone G and found that it inhibited Hepatitis C replication, but not Sendai or Vesicular Stomatitis Virus. Pre- and post-infection treatments demonstrated anti-flaviviral activity against Dengue and Zika virus, via viral RNA polymerase inhibition. These data suggest that Sophoraflavenone G represents a promising candidate regarding anti-Flaviviridae research.
- Subjects
PHYTONCIDES; DENGUE; THERAPEUTICS; ZIKA virus infections; RNA polymerases; HEPATITIS C treatment; ANTIVIRAL agents
- Publication
Viruses (1999-4915), 2017, Vol 9, Issue 10, p287
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v9100287