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- Title
Impact of Premature Ovarian Failure on Mortality and Morbidity among Chinese Women.
- Authors
Wu, Xiaoyan; Cai, Hui; Kallianpur, Asha; Li, Honglan; Yang, Gong; Gao, Jing; Xiang, Yong-Bing; Ji, Bu-Tian; Yu-Tang; Zheng, Wei; Shu, Xiao-Ou
- Abstract
Objective: To evaluate associations of premature ovarian failure (POF) with mortality and morbidity in Asian populations. Methods: We identified 1,003 cases of POF among 36,402 postmenopausal women who participated in the Shanghai Women's Health Study, a population-based cohort study. Cox regression and logistic regression models were applied in data analysis. Results: After adjustment for potential confounding factors, we found that POF increased the risk of total and cancer-specific mortality (HR (95%CIs): 1.29 (1.08–1.54) and 1.38 (1.05–1.81), respectively). POF was also associated with high prevalence of autoimmune disease (OR (95%CI): 1.56 (1.04–2.35)) but decreased incidence of breast cancer (OR (95%CI): 0.59 (0.38–0.91)). Similar results were observed when hormone replacement therapy users were excluded from the analysis. POF is associated with high waist-to-hip ratio. Conclusions: Our results suggest that women with POF experience increased mortality and that these women may benefit from heightened surveillance and appropriate interventions.
- Subjects
OVARIAN diseases; CHINESE people; POSTMENOPAUSE; COHORT analysis; WOMEN'S health; AUTOIMMUNE diseases; POPULATION biology; EPIDEMIOLOGY; DISEASES
- Publication
PLoS ONE, 2014, Vol 9, Issue 3, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0089597