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- Title
B Cells Promote Tumor Progression via STAT3 Regulated-Angiogenesis
- Authors
Yang, Chunmei; Lee, Heehyoung; Pal, Sumanta; Jove, Veronica; Deng, Jiehui; Zhang, Wang; Hoon, Dave S. B.; Wakabayashi, Mark; Forman, Stephen; Yu, Hua
- Abstract
The role of B cells in cancer and the underlying mechanisms remain to be further explored. Here, we show that tumor-associated B cells with activated STAT3 contribute to tumor development by promoting tumor angiogenesis. B cells with or without Stat3 have opposite effects on tumor growth and tumor angiogenesis in both B16 melanoma and Lewis Lung Cancer mouse models. Ex vivo angiogenesis assays show that B cell-mediated tumor angiogenesis is mainly dependent on the induction of pro-angiogenic gene expression, which requires Stat3 signaling in B cells. Furthermore, B cells with activated STAT3 are mainly found in or near tumor vasculature and correlate significantly with overall STAT3 activity in human tumors. Moreover, the density of B cells in human tumor tissues correlates significantly with expression levels of several STAT3-downstream pro-angiogenic genes, as well as the degree of tumor angiogenesis. Together, these findings define a novel role of B cells in promoting tumor progression through angiogenesis and identify STAT3 in B cells as potential therapeutic target for anti-angiogenesis therapy.
- Subjects
B cells; CANCER invasiveness; GENETIC regulation; NEOVASCULARIZATION; STAT proteins; CELLULAR signal transduction; CANCER treatment
- Publication
PLoS ONE, 2013, Vol 8, Issue 5, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0064159