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- Title
IL-10 Regulates Viral Lung Immunopathology during Acute Respiratory Syncytial Virus Infection in Mice.
- Authors
Loebbermann, Jens; Schnoeller, Corinna; Thornton, Hannah; Durant, Lydia; Sweeney, Nathan P.; Schuijs, Martijn; O'Garra, Anne; Johansson, Cecilia; Openshaw, Peter J.
- Abstract
Interleukin (IL-) 10 is a pleiotropic cytokine with broad immunosuppressive functions, particularly at mucosal sites such as the intestine and lung. Here we demonstrate that infection of BALB/c mice with respiratory syncytial virus (RSV) induced IL- 10 production by CD4+ and CD8+ T cells in the airways at later time points (e.g. day 8); a proportion of these cells also coproduced IFN-γ. Furthermore, RSV infection of IL-10-/- mice resulted in more severe disease with enhanced weight loss, delayed recovery and greater cell infiltration of the respiratory tract without affecting viral load. In addition, IL-10-/- mice had a pronounced airway neutrophilia and heightened levels of pro-inflammatory cytokines and chemokines in the bronchoalveolar lavage fluid. Notably, the proportion of lung T cells producing IFN-γ was enhanced, suggesting that IL-10 may act in an autocrine manner to dampen effector T cell responses. Similar findings were made in mice treated with anti- IL-10R antibody and infected with RSV. Therefore, IL-10 inhibits disease and inflammation in mice infected with RSV, especially during recovery from infection.
- Subjects
IMMUNOPATHOLOGY; LUNGS; RESPIRATORY syncytial virus; LABORATORY mice; INTERLEUKINS; CYTOKINES
- Publication
PLoS ONE, 2012, Vol 7, Issue 2, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0032371