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- Title
Action Mechanism of Extracts from Cerasus serrulata Flower for Hair-Blacking in C57BL/6 Mice.
- Authors
Zhang, Bing; Zhang, Wenyun; Luo, Jianfang; He, Jian; Rong, Baoshan; Zheng, Xiaomin; Zhu, Siyang; Xu, Xian; Ai, Yong; Zhang, Lanyue; He, Tinggang
- Abstract
Background: Hair color retention and rejuvenation have recently emerged as a new research hot spot, with many studies focused on developing treatments to prevent premature greying. Aim: This study is aimed to explore the hair-blacking effects and possible mechanisms of Cerasus serrulata flower extracts (CSE) using a C57BL/6 premature greying mouse model. Materials and Methods: The variations in hair follicle number, hair follicle depth and cortical thickness were evaluated by hematoxylin and eosin staining. The quantity changes of melanocytes were also evaluated using Masson-Fontana Melanin staining. The relative abundance of vascular endothelial growth factor (VEGF), β-catenin and tyrosinase transcripts following transformed growth were further quantified using RT-qPCR and immunofluorescence. The changes in protein level expression of β-catenin, VEGF and tyrosinase were also evaluated by western blot. Results: The β-catenin and VEGF expression were significantly up-regulated in skin tissues treated with C. serrulata extracts, promoting hair growth and blackening. Conclusion: CSE can promote the efficient hair-blacking likely via the VEGF pathway, making it a potential therapeutic candidate for treating premature greying.
- Subjects
MICROPHTHALMIA-associated transcription factor; HAIR growth; LABORATORY mice; VASCULAR endothelial growth factors; HEMATOXYLIN &; eosin staining; HAIR follicles; HAIR dyeing &; bleaching
- Publication
Pharmacognosy Magazine, 2023, Vol 19, Issue 2, p303
- ISSN
0973-1296
- Publication type
Article
- DOI
10.1177/09731296231157182