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- Title
Frequency and Risk Factors of Penicillin and Amoxicillin Allergy in Suspected Patients with Drug Allergy.
- Authors
Fazlollahi, Mohammad Reza; Bidad, Katayoon; Shokouhi, Raheleh; Dashti, Raheleh; Nabavi, Mohammad; Movahedi, Masoud; Bemanian, Mohammad Hasan; Shafiei, Ali Reza; Kalantari, Najmoddin; Farboud, Effat Sadat; Pourpak, Zahra; Moin, Mostafa
- Abstract
Background: Unconfirmed beta-lactam allergy is a significant public health problem because of the limitations it imposes in drug selection. In this study, we aimed to evaluate patients referred for beta-lactam allergy to determine the frequency of confirmed beta-lactam allergy and identify some risk factors. Methods: In a prospective cohort study, all referred patients to Immunology, Asthma and Allergy Research Institute in Tehran University of Medical Sciences (between 2007 - 2009) who suspected to have beta-lactam allergy were entered into this study based on having the inclusion criteria. Follow-up was performed 6-8 years after the final diagnosis. Diagnosis of beta-lactam allergy relies on thorough history and specific IgE measurements (ImmunoCAP), skin prick testing (SPT), intradermal testing (IDT), patch testing, and oral drug challenge test. Results: Fifty-one patients with mean age of 24.5 (±18.5) years were enrolled in this study. Based on workups, beta-lactam allergy was confirmed in 16 (31.4%) patients, suspicious in 22 (43.1%) patients and ruled out in 13 (25.5%) patients. During the follow-up, 3 patients with suspicious drug allergy consumed the culprit drug with no reaction so allergy was finally ruled out in 16 (31.4%) patients. Age, sex, atopy and family history of drug allergies were not significantly different between the patients with confirmed or ruled-out diagnosis of penicillin and amoxicillin allergy. Conclusion: At least up to one-third of patients with a history of beta-lactam allergy are proven to be safe using the drug. Also, a clear protocol consists of serum slgE assay and SPT can be helpful to the physicians in the health care system.
- Subjects
IRAN; PREVENTION of drug side effects; DRUG allergy; ALLERGIES; AMOXICILLIN; CHI-squared test; LONGITUDINAL method; PENICILLIN; T-test (Statistics); DATA analysis software; DESCRIPTIVE statistics
- Publication
Archives of Iranian Medicine (AIM), 2017, Vol 20, Issue 1, p34
- ISSN
1029-2977
- Publication type
Article