We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impacts of tissue-type plasminogen activator (tPA) on neuronal survival.
- Authors
Chevilley, Arnaud; Lesept, Flavie; Lenoir, Sophie; Ali, Carine; Parcq, Jérôme; Vivien, Denis; Ellis, Vince; Samson, Andre Laval
- Abstract
Tissue-type plasminogen activator (tPA) a serine protease is constituted of five functional domains through which it interacts with different substrates, binding proteins, and receptors. In the last years, great interest has been given to the clinical relevance of targeting tPA in different diseases of the central nervous system, in particular stroke. Among its reported functions in the central nervous system, tPA displays both neurotrophic and neurotoxic effects. How can the protease mediate such opposite functions remain unclear but several hypotheses have been proposed. These include an influence of the degree of maturity and/or the type of neurons, of the level of tPA, of its origin (endogenous or exogenous) or of its form (single chain tPA versus two chain tPA). In this review, we will provide a synthetic snapshot of our current knowledge regarding the natural history of tPA and discuss how it sustains its pleiotropic functions with focus on excitotoxic/ischemic neuronal death and neuronal survival.
- Subjects
TISSUE plasminogen activator; APOPTOSIS; METHYL aspartate receptors; CIRCULATING anticoagulants; SERINE proteinases
- Publication
Frontiers in Cellular Neuroscience, 2015, Vol 9, p1
- ISSN
1662-5102
- Publication type
Article
- DOI
10.3389/fncel.2015.00415