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- Title
Interleukin-6 mediates lung injury following ischemic acute kidney injury or bilateral nephrectomy.
- Authors
Klein, Christina L; Hoke, Tom S.; Wen-Feng Fang; Altmann, Christopher J.; Douglas, Ivor S.; Faubel, Sarah
- Abstract
Patients with acute kidney injury frequently have pulmonary complications. Similarly ischemic acute kidney injury or bilateral nephrectomy in rodents causes lung injury characterized by pulmonary edema, increased pulmonary capillary leak and interstitial leukocyte infiltration. Interleukin-6 is a pro-inflammatory cytokine that is increased in the serum of patients with acute kidney injury and predicts mortality. Here we found that lung neutrophil infiltration, myeloperoxidase activity, the neutrophil chemokines KC and MIP-2 and capillary leak all increased within 4 h following acute kidney injury in wild-type mice. These pathologic factors were reduced in interleukin-6-deficient mice following acute kidney injury or bilateral nephrectomy. The lungs of mutant mice had reduced KC but MIP-2 was similar to that of wild type mice. Wild-type mice, treated with an interleukin-6 inactivating antibody, had decreased lung myeloperoxidase activity and KC levels following acute kidney injury. Our study shows that interleukin-6 contributes to lung injury following acute kidney injury.Kidney International (2008) 74, 901–909; doi:10.1038/ki.2008.314; published online 2 July 2008
- Subjects
KIDNEY injuries; INTERLEUKIN-6; LUNG injuries; KIDNEY surgery; CHEMOKINES; NEUTROPHILS
- Publication
Kidney International, 2008, Vol 74, Issue 7, p901
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2008.314