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- Title
One-pot synthesis of 3,5-diaryl substituted-1,2,4-oxadiazoles using gem-dibromomethylarenes.
- Authors
Vinaya, Kambappa; Chandrashekara, Ganganahalli K.; Shivaramu, Prasanna D.
- Abstract
1,2,4-Oxadiazole is one of the most promising heterocyclic ring systems in medicinal chemistry. In the present paper, we report the method for an efficient one-pot synthesis of 3,5-diaryl substituted 1,2,4-oxadiazoles using a two-component reaction of gem-dibromomethylarenes with amidoximes in good yields. In this method, gem-dibromomethylarenes are used as benzoic acid equivalents for the efficient synthesis of aryl-substituted 1,2,4-oxadiazoles. It is anticipated that this methodology will have versatile applications in the practical syntheses of various molecules of both medicinal and material chemistry importance.
- Subjects
PHARMACEUTICAL chemistry; BENZOIC acid
- Publication
Canadian Journal of Chemistry, 2019, Vol 97, Issue 9, p690
- ISSN
0008-4042
- Publication type
Article
- DOI
10.1139/cjc-2018-0333