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- Title
Graphene nanosheets as a sensing platform for amplified electrochemical measurement of quercetin and uric acid in biological fluids.
- Authors
Arvand, Majid; Anvari, Mohsen
- Abstract
A simple and selective electrochemical method was investigated for the simultaneous determination of quercetin (Qu) and uric acid (UA) in aqueous media (citrate buffer solution, pH 4.0) on a glassy carbon electrode modified with graphene nanosheets as a sensing platform (GNSs/GCE). Cyclic voltammetry, transmission electron microscopy, and Fourier transform infrared spectroscopy were employed to characterize the nanostructure of the sensor. Separation of the oxidation peak potentials for Qu and UA was about 160 mV, and the anodic currents for the oxidation of both Qu and UA are greatly increased at GNSs/GCE, which makes it suitable for simultaneous determination of these compounds. The detection limits were 0.0011 and 0.0137 μmol/L for Qu and UA, respectively. The method was applied to the determination of Qu and UA in human blood serum and urine samples.
- Subjects
GRAPHENE; QUERCETIN; URIC acid; ELECTROCHEMICAL analysis; BIOLOGICAL fluid dynamics; CYCLIC voltammetry; TRANSMISSION electron microscopy
- Publication
Canadian Journal of Chemistry, 2014, Vol 92, Issue 11, p1074
- ISSN
0008-4042
- Publication type
Article
- DOI
10.1139/cjc-2014-0264