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- Title
Use of midazolam in palliative care.
- Authors
McNamara, Paul; Minton, Michael; Twycross, Robert G
- Abstract
Objective: To review the use of midazolam (a water-soluble benzodiazepine) in terminally ill patients.Design: A retrospective study of 104 patients.Results: Midazolam was used intravenously as sedation before minor procedures in three patients. Because of prolonged sedation in two patients, the following regimen is now used: 1 mg intravenously stat, followed by 1 mg/min, or 0.5mg/min in those over 65. In other situations, midazolam was used subcutaneously (SC), usually via a syringe driver. For muscle relaxation the median dose was 30mg SC/24h (27 patients; range 10-60mg). When treating terminal agitated delirium the median dose was 35mg SC/24h (61 patients; range 10-240mg). For multifocal myoclonus or as prophylaxis against fits the median dose was 30mg SC/24h (12 patients; range 15-80mg).
- Publication
Palliative Medicine, 1991, Vol 5, Issue 3, p244
- ISSN
0269-2163
- Publication type
Article
- DOI
10.1177/026921639100500310