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- Title
Effects of a Monoclonal Antibody Raised Against Nerve Growth Factor on Skeletal Pain and Bone Healing After Fracture of the C57BL/6J Mouse Femur.
- Authors
Koewler, Nathan J.; Freeman, Katie T.; Buus, Ryan J.; Herrera, Monica B.; Jimenez-Andrade, Juan M.; Ghilardi, Joseph R.; Peters, Christopher M.; Sullivan, Lucy J.; Kuskowski, Michael A.; Lewis, Jack L.; Mantyh, Patrick W.
- Abstract
The article demonstrates a stereotypic progression of skeletal remodeling and pain-related behaviors after fracture of the femur in young adult C57 mice. According to the authors, administration of anti-nerve growth factor (NGF) therapy resulted in a reduction of fracture-induced pain without negatively influencing bone healing. They add that anti-NGF therapy did not modify biomechanical properties of the femur or histomorphometric indices of bone healing.
- Subjects
FEMUR; BONE fractures; LABORATORY mice; NERVE growth factor; PAIN management; HEALING; THERAPEUTICS
- Publication
Journal of Bone & Mineral Research, 2007, Vol 22, Issue 11, p1732
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1359/JBMR.070711