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- Title
The role of Semaphorin 3A in oral diseases.
- Authors
Zhang, Xinyue; Yang, Zhenqi; Zhang, Demao; Bai, Mingru
- Abstract
Semaphorin 3A (SEMA3A), also referred to as H‐Sema III, is a molecule with significant biological importance in regulating physiological and pathological processes. However, its role in oral diseases, particularly its association with inflammatory immunity and alveolar bone remodeling defects, remains poorly understood. This comprehensive review article aims to elucidate the recent advances in understanding SEMA3A in the oral system, encompassing nerve formation, periodontitis, pulpitis, apical periodontitis, and oral squamous cell carcinoma. Notably, we explore its novel function in inflammatory immunomodulation and alveolar bone formation during oral infectious diseases. By doing so, this review enhances our comprehension of SEMA3A's role in oral biology and opens up possibilities for modulatory approaches and potential treatments in oral diseases.
- Subjects
INFLAMMATION prevention; SQUAMOUS cell carcinoma; COMMUNICABLE diseases; MOUTH tumors; HEAD &; neck cancer; BONE growth; DENTAL pulp diseases; PERIAPICAL diseases; TRIGEMINAL nerve; IMMUNE system; ORAL diseases; GROWTH factors; IMMUNOMODULATORS; BONE remodeling; ALVEOLAR process; PERIODONTITIS; IMMUNITY
- Publication
Oral Diseases, 2024, Vol 30, Issue 4, p1887
- ISSN
1354-523X
- Publication type
Article
- DOI
10.1111/odi.14748