We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The evil companion of OSCC: Candida albicans.
- Authors
Yang, Zhixin; Zhang, Shiyu; Ji, Ning; Li, Jing; Chen, Qianming
- Abstract
Objective: Microbial dysbiosis and microbiome‐induced inflammation may play a role in the etiopathogenesis of oral squamous cell carcinoma (OSCC). Candida albicans (C. albicans) is the most prevalent opportunistic pathogenic fungus in the oral cavity, and Candida infection is considered as one of its high‐risk factors. Although oral microbiota–host interactions are closely associated with the development of OSCC, the interrelationship between fungi and OSCC is poorly understood compared to that between bacteria and viruses. Results: We accumulated knowledge of the evidence, pathogenic factors, and possible multiple mechanisms by which C. albicans promotes malignant transformation of OSCC, focusing on the induction of epithelial damage, production of carcinogens, and regulation of the tumor microenvironment. In addition, we highlight the latest treatment strategies for Candida infection. Conclusion: This review provides a new perspective on the interrelationship between C. albicans and OSCC and contributes to the establishment of a systematic and reliable clinical treatment system for OSCC patients with C. albicans infection.
- Subjects
SQUAMOUS cell carcinoma; MOUTH tumors; OPPORTUNISTIC infections; NEOPLASTIC cell transformation; GUT microbiome; CANDIDA albicans; METASTASIS; CARCINOGENS; INFLAMMATION; DISEASE progression
- Publication
Oral Diseases, 2024, Vol 30, Issue 4, p1873
- ISSN
1354-523X
- Publication type
Article
- DOI
10.1111/odi.14700