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- Title
Surface Antigen Changes Accompanying Lymphocyte Activation.
- Authors
Kerbel, R.S.
- Abstract
It is here shown that some noncongenic anti-H-2 antisera produced by using normal spleen cells as the immunogen can contain cytotoxic antibody activity against activated, bet not resting, lymphocytes of unrelated H-2 haplotype strains. Reactivity was noted against lymphocytes activated in vitro with T- or B-cell mitogens, or in vivo by antigenic stimulation. Analysis of the results indicated that the anti-activated lymphocyte activity was most likely related to production of anti-Ala-1 (`activated lymphocyte antigen) alloantibodies. This appears to occur as a result of donor lymphocyte activation during production of the anti-H-2 antisera, using Ala-1-incompatible donor and recipient combinations, where the donor cells art competent to recognize and react against host H-2 incompatibilities. These results confirm the finding that lymphocyte activation can be accompanied by the expression of an antigen that is either absent or weakly expressed on resting lymphocytes.
- Subjects
CELL surface antigens; SPLEEN; CELLS; LYMPHOCYTES; B cells; MITOGENS
- Publication
Scandinavian Journal of Immunology, 1977, Vol 6, Issue 10, p1029
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1977.tb00339.x