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- Title
Further Studies on the Mixed Leukocyte Reaction in Multiple Sclerosis and Various Arthritides.
- Authors
Hedberg, H.; Källén, B.; Löw, B.; Nilsson, O.
- Abstract
The mixed leukocyte reaction (MLR) is impaired in multiple sclerosis and certain arthritides, notably rheumatoid arthritis. The present study shows that this phenomenon is not disease-specific: cells from patients with multiple sclerosis react poorly also with cells from patients with arthritis. A time study of the reaction excludes the possibility of an initial strong MLR followed by cell death -- a phenomenon sometimes seen in animal experiments. A study of the effect of patient sera on a two-way MLR between normal individuals shows that a small depressive effect is present with the patient sera, but this is not of the magnitude that it can explain the MLR impairment under study.
- Subjects
MULTIPLE sclerosis; VIRUS diseases; ARTHRITIS; JOINT diseases; RHEUMATOID arthritis; CELL death
- Publication
Scandinavian Journal of Immunology, 1973, Vol 2, Issue 3, p291
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1973.tb02038.x