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- Title
The association of vitamin D supplementation and serum vitamin D levels with physical activity in older adults: Results from a randomized trial.
- Authors
Schrack, Jennifer A.; Cai, Yurun; Urbanek, Jacek K.; Wanigatunga, Amal A.; Mitchell, Christine M.; Miller, Edgar R.; Guralnik, Jack M.; Juraschek, Stephen P.; Michos, Erin D.; Roth, David L.; Appel, Lawrence J.
- Abstract
Background: To assess whether vitamin D3 supplementation attenuates the decline in daily physical activity in low‐functioning adults at risk for falls. Methods: Secondary data analyses of STURDY (Study to Understand Fall Reduction and Vitamin D in You), a response‐adaptive randomized clinical trial. Participants included 571 adults aged 70 years and older with baseline serum 25(OH)D levels of 10–29 ng/mL and elevated fall risk, who wore a wrist accelerometer at baseline and at least one follow‐up visit and were randomized to receive: 200 IU/day (control), 1000, 2000, or 4000 IU/day of vitamin D3. Objective physical activity quantities and patterns (total daily activity counts, active minutes/day, and activity fragmentation) were measured for 7‐days, 24‐h/day, in the free‐living environment using the Actigraph GT9x over up to 24‐months of follow‐up. Results: In adjusted models, physical activity quantities declined (p < 0.001) and became more fragmented, or "broken up", (p = 0.017) over time. Supplementation with vitamin D3 did not attenuate this decline. Changes in physical activity were more rapid among those with baseline serum 25(OH)D <20 ng/mL compared to those with baseline 25(OH)D levels of 20–29 ng/mL (time*baseline 25(OH)D, p < 0.05). Conclusion: In low‐functioning older adults with serum 25(OH)D levels 10–29 ng/mL, vitamin D3 supplementation of 1000 IU/day or higher did not attenuate declines in physical activity compared with 200 IU/day. Those with baseline 25(OH)D <20 ng/mL showed accelerated declines in physical activity. Alternative interventions to supplementation are needed to curb declines in physical activity in older adults with low serum 25(OH)D.
- Subjects
FUNCTIONAL status; DIETARY supplements; VITAMIN D; TREATMENT effectiveness; PHYSICAL activity; ACCELEROMETRY; FUNCTIONAL assessment; ACCIDENTAL falls; DESCRIPTIVE statistics; VITAMIN D deficiency; SECONDARY analysis; EVALUATION; OLD age
- Publication
Journal of the American Geriatrics Society, 2023, Vol 71, Issue 7, p2208
- ISSN
0002-8614
- Publication type
Article
- DOI
10.1111/jgs.18290