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- Title
Epidemiologic and biologic characterization of a cohort of human immunodeficiency virus type 1 highly exposed, persistently seronegative female sex workers in northern Thailand. Chiang Mai HEPS Working Group.
- Authors
Beyrer, Chris; Artenstein, Andrew W.; Rugpao, Sungwal; Stephens, Henry; VanCott, Thomas C.; Robb, Merlin L.; Rinkaew, Maneerat; Birx, Deborah L.; Khamboonruang, Chirasak; Zimmerman, Peter A.; Nelson, Kenrad E.; Natpratan, Chawalit; Beyrer, C; Artenstein, A W; Rugpao, S; Stephens, H; VanCott, T C; Robb, M L; Rinkaew, M; Birx, D L
- Abstract
Characterization of persons highly exposed to human immunodeficiency virus (HIV)-1 who remain uninfected may help define protective immunity. Seventeen HIV-1-seronegative Thai female sex workers (CSWs) with epidemiologic evidence of exposure to HIV-1 were studied for humoral immune responses and phenotypic and genotypic analyses of HLA class I and CCR5 allelic profiles. Infected CSWs and low-risk HIV-1-seronegative Thai women were controls. Highly exposed, persistently seronegative (HEPS) CSWs did not differ from HIV-infected CSWs in HIV risks, condom use, or sexually transmitted diseases. Significant differences were seen in humoral immune responses: gp160-specific IgA responses were detected in cervicovaginal lavage fluids in 6 of 13 HEPS CSWs but 0 of 21 seronegative subjects. All women had wild-type CCR5. HEPS CSWs were more likely to have the HLA-B18 phenotype and genotype than were matched controls (corrected P=.018). Epidemiologic exposure to HIV-1 without apparent infection, an unusual distribution of HLA class I alleles, and HIV-1 gp160-specific IgA responses suggest a biologic basis for this phenomenon.
- Subjects
NORTHERN Thailand; HIV-positive women; HIV infections; HIV; DISEASES; SEX workers
- Publication
Journal of Infectious Diseases, 1999, Vol 179, Issue 1, p59
- ISSN
0022-1899
- Publication type
journal article