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- Title
Bone marrow Dikkopf‐1 levels are a new independent risk factor for progression in patients with smouldering myeloma.
- Authors
Dalla Palma, Benedetta; Marchica, Valentina; Pedrazzoni, Mario; Accardi, Fabrizio; Notarfranchi, Laura; Goldoni, Matteo; De Luca, Federica; Costa, Federica; Storti, Paola; Toscani, Denise; Sammarelli, Gabriella; Bonomini, Sabrina; Aversa, Franco; Giuliani, Nicola
- Abstract
The article presents a study which examined the possible role played by bone marrow (BM) levels of such cytokines and chemokines as Activin A, C-C motif chemokine ligand 20 (CCL20), and Dickkopf 1 (DKK-1) in the progression of smouldering multiple myeloma (MM) in patients. Topics include the role of DKK-1 in tumoural progression via the increase in the number of myeloid-derived suppressor cells (MDSC) and the use of enzyme-linked immunosorbent assay (ELISA) kits in BM plasma analysis.
- Subjects
MULTIPLE myeloma; CYTOKINES; BONE marrow; CHEMOKINES; CANCER invasiveness; ENZYME-linked immunosorbent assay
- Publication
British Journal of Haematology, 2018, Vol 183, Issue 5, p812
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.15026