We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Seroprevalence of acute dengue in a Malaysian tertiary medical centre.
- Authors
Chuan Hun Ding; Rashid, Zetti Zainol; Rahman, Md. Mostafizur; Nan Feng Khang; Wan Ngor Low; Hussin, Nurabrar; Marzuki, Melissa Iqlima; Jaafar, Alyaa Nadhira; Roslan, Nurul Ain' Nabilla; Chandrasekaran, Terukumar
- Abstract
Objectives: The aims of this study were to determine the seroprevalence of acute dengue in Universiti Kebangsaan Malaysia (UKM) Medical Centre and its correlation with selected haematological and biochemical parameters. Methods: This cross-sectional study was conducted from January to June 2015. A patient was serologically diagnosed with acute dengue if the dengue virus IgG, IgM or NS-1 antigen was reactive. Results: Out of 1,774 patients suspected to have acute dengue, 1,153 were serologically diagnosed with the infection, resulting in a seroprevalence of 64.9%. Dengue-positive patients had a lower mean platelet count (89 x 109/L) compared to the dengue-negative patients (171 x 109/L) (p<0.0001). The mean total white cell count was also lower in the dengue-positive cases (4.7 x 109/L vs. 7.2 x 109/L; p<0.0001). The mean haematocrit was higher in patients with acute dengue (42.5% vs. 40.0%; p<0.0001). Likewise, the serum alanine transaminase level was also higher in patients with acute dengue (108 U/L vs. 54 U/L; p<0.0001). Conclusions: Dengue is very prevalent in UKM Medical Centre as most patients suspected to have acute dengue had serological evidence of the infection. The platelet count was the single most likely parameter to be abnormal (i.e. low) in patients with acute dengue.
- Subjects
MALAYSIA; SEROPREVALENCE; DENGUE; DENGUE viruses; PLATELET count; PUBLIC health; HEMATOCRIT
- Publication
Pakistan Journal of Medical Sciences, 2016, Vol 32, Issue 2, p495
- ISSN
1682-024X
- Publication type
Article
- DOI
10.12669/pjms.322.9320