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- Title
Rationally improving LOV domain-based photoswitches.
- Authors
Strickland, Devin; Xiaolan Yao; Gawlak, Grzegorz; Rosen, Michael K.; Gardner, Kevin H.; Sosnick, Tobin R.
- Abstract
Genetically encoded protein photosensors are promising tools for engineering optical control of cellular behavior; we are only beginning to understand how to couple these light detectors to effectors of choice. Here we report a method that increases the dynamic range of an artificial photoswitch based on the LOV2 domain of Avena sativa phototropin 1 (AsLOV2). This approach can potentially be used to improve many AsLOV2-based photoswitches.
- Subjects
OPTOELECTRONIC devices; PROTEINS; LIGHT; OXYGEN; ELECTRIC potential; GENETIC engineering equipment
- Publication
Nature Methods, 2010, Vol 7, Issue 8, p623
- ISSN
1548-7091
- Publication type
Article
- DOI
10.1038/nmeth.1473