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- Title
Upregulation of ICAM-1 in diabetic rats after transient forebrain ischemia and reperfusion injury.
- Authors
Li Jing; Jian-Gang Wang; Jian-Zhong Zhang; Cai-Xia Cao; Yue Chang; Jian-Da Dong; Feng-Ying Guo; Li, P. Andy
- Abstract
Background Hyperglycemia exacerbates brain damage caused by cerebral ischemia. Neuroinflammation may play a role in mediating such enhanced damage. The objectives of this study were to examine the mRNA and protein levels and cell type distribution of ICAM-1 after cerebral ischemia in normo-and diabetic hyperglycemic rats. Results Compared to normoglycemic ischemia animals, diabetes aggravated neuronal death, decreased Nissl body staining, and increased ICAM-1 mRNA and protein levels in the frontal cortex. The increased ICAM-1 was located not only in vascular endothelial cells but also in cortical neurons. Conclusions Our results suggest that exacerbated neuro-inflammation in the brain may mediate the detrimental effects of diabetes on the ischemic brain.
- Subjects
ISCHEMIA; LABORATORY rats; REPERFUSION injury; MESSENGER RNA; MRNA guanylyltransferase
- Publication
Journal of Inflammation, 2014, Vol 11, Issue 1, p1
- ISSN
1476-9255
- Publication type
Article
- DOI
10.1186/s12950-014-0035-2