We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Circulating vitamin D and the risk of gestational diabetes: a systematic review and dose-response meta-analysis.
- Authors
Sadeghian, Mehdi; Asadi, Maryam; Rahmani, Sepideh; Akhavan Zanjani, Mohsen; Sadeghi, Omid; Hosseini, Seyed Ahmad; Zare Javid, Ahmad
- Abstract
Purpose: Several meta-analyses of observational studies revealed a modest increase in the risk of gestational diabetes (GDM) among pregnant women with low levels of serum vitamin D. However, no study examined a dose-response meta-analysis as well as a high versus low analysis in this regard. Methods: We systematically searched PubMed, Embase, ISI Web of Science, and Scopus up to August 2019 to find prospective observational studies investigating the association of serum 25(OH)D with the risk of developing GDM. Using a random-effects model, the reported risk estimates were pooled. Results: Nine cohort studies and six nested case-control studies were included in the final analysis (40,788 participants and 1848 cases). Considering linear analysis, each 10 nmol/L increase in circulating 25(OH)D was associated with a 2% lower risk of GDM (effect size (ES): 0.98; 95% CI: 0.98, 0.99; I2 = 85.0%, P < 0.001). highest compared with the lowest category of circulating 25(OH)D was associated with a 29% lower risk of GDM, with low evidence of heterogeneity (I2 = 45.0%, P = 0.079). Conclusions: In conclusion, lower levels of serum 25(OH)D were associated with a higher chance of GDM. Differential results existed between the overall and subgroup analysis, either based on vitamin D detection methods or based on maternal age, although these subgroups partially lowered the heterogeneity.
- Publication
Endocrine (1355008X), 2020, Vol 70, Issue 1, p36
- ISSN
1355-008X
- Publication type
Article
- DOI
10.1007/s12020-020-02360-y