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- Title
INCIDENCE AND RISK FACTORS OF POSTNATAL CYTOMEGALOVIRUS INFECTION IN VERY LOW BIRTH WEIGHT INFANTS.
- Authors
Naho Ikeda; Hiromichi Shoji; Hiroki Suganuma; Natsuki Ohkawa; Yayoi Murano
- Abstract
Introduction. Premature infants have a high risk of acquired Cytomegalovirus (CMV) infection from own mother’s or donor’s breast milk and from the blood transfusion. The aim of this study was to examine the morbidity and risk factors for postnatal CMV infection in very low birth weight (VLBW) infants. Methods. The study was performed at the NICU of Juntendo University Shizuoka Hospital, Japan. VLBW infants admitted to the unit from October 2010 to August 2013 were the subjects of this study. Spot urine samples were obtained at birth and discharge. Urinary CMV was analysed by loopmediated isothermal amplification. Data collected included the clinical course, history of blood transfusion and feeding with donor breast milk. We compared the results between the postnatal CMV infection group (pCMV: negative at birth and positive at discharge) and no infection group (no CMV). Results. There were 2 infants with prenatal CMV and 8 with pCMV; 60 infants had no infection. The mean gestational age at birth was 27.7 ± 3.4 weeks for the pCMV group and 28.2 ± 2.4 weeks for the no CMV group. The median BW at birth was 846 ± 359 g for the pCMV group and 1006 ± 251 g for the no CMV group. Complications including CLD and PVL and the requirement for home oxygen therapy (HOT) were significantly higher in the pCMV group than in the no CMV group (p < 0.01). Discussion. In this study, the rate of postnatal CMV infection in VLBW infants was 11.8% and severe symptoms did not develop in any infant. Besides, postnatal CMV infection may lead to complications including CLD and PVL and may require HOT.
- Subjects
JAPAN; SERBIA; CYTOMEGALOVIRUS diseases; LOW birth weight; CONFERENCES &; conventions; DISEASES; PUERPERIUM; DISEASE risk factors
- Publication
Journal of Perinatal Medicine, 2017, Vol 45, p170
- ISSN
0300-5577
- Publication type
Article
- DOI
10.1515/jpm-2017-3001