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- Title
Long chain polyunsaturated fatty acids in mothers of preterm babies.
- Authors
Kilari, Anitha S.; Mehendale, Savita S.; Dangat, Kamini D.; Yadav, Hemalata R.; Gupta, Arti; Taralekar, Vaishali S.; Joshi, Sadhana R.
- Abstract
Aims: To examine the levels of docosahexaenoic acid (DHA) and arachidonic acid (AA) in both plasma and erythrocytes of maternal and cord blood as well as in breast milk of mothers of preterm babies. Methods: A total of 63 mothers of preterm babies were recruited from the Bharati Medical Hospital, Pune, India. Results: Plasma and erythrocyte DHA and AA levels were higher (P<0.001) in cord blood than in maternal blood. Maternal plasma DHA and AA were positively (P<0.01) associated with their respective maternal erythrocyte levels. There was a positive association (P<0.01) between maternal DHA (both plasma and erythrocyte) and cord DHA. Maternal plasma omega 3 and 6 fatty acids were positively (P<0.01) associated with their respective milk fatty acids. Conclusions: Higher DHA and AA levels in cord blood compared to the mothers suggests a special mechanism to meet the increased demand of the fetus. Higher levels of milk DHA reflect the increased postnatal requirement of preterm babies suggesting a vital role for maternal milk. Lower maternal erythrocyte DHA concentrations in mothers delivering preterm as compared to term suggest that increased oxidative stress may be responsible for reduced DHA levels. This may alter the uterotonic factors like prostaglandins leading to premature triggering of labor.
- Subjects
INDIA; ACADEMIC medical centers; ANALYSIS of variance; ARACHIDONIC acid; BREAST milk; COMPUTER software; CORD blood; PREMATURE infants; EVALUATION of medical care; STATISTICS; T-test (Statistics); UNSATURATED fatty acids; DOCOSAHEXAENOIC acid; DATA analysis; BLOOD; PREGNANCY
- Publication
Journal of Perinatal Medicine, 2010, Vol 38, Issue 6, p659
- ISSN
0300-5577
- Publication type
Article
- DOI
10.1515/JPM.2010.112