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- Title
Fetal protective effect of Indonesian propolis from Apis mellifera against rifampicin-pyrazinamide induced impaired pregnancy in BALB/c mice.
- Authors
Abdillah, Rahmad; Rachmaini, Fitri; Fadhilah, Dinda; Almahdy, Almahdy
- Abstract
Anti-tuberculosis drugs rifampicin and pyrazinamide combination in pregnancy can cause morphological, visceral and skeletal damage. Several studies showed that propolis improves pregnancy outcomes. This study aims to determine the fetal protective effect of propolis in BALB/c mice given the anti-tuberculosis drug combination rifampicin and pyrazinamide. A total of 21 pregnant mice were randomly divided into three groups: the normal group (N) was given distilled water as a vehicle, the positive control group (RP) were given rifampicin 15 mg/kg BW, pyrazinamide 35 mg/kg BW and the treatment group (IP) were given rifampicin 15 mg/kg BB, pyrazinamide 35 mg/kg BW and propolis 400 mg/kg BW. The treatment was given during the period of organogenesis, from day 6 to day 15. Laparotomy was performed on the 18th day of pregnancy. Maternal and fetal body weight, fetal length, number of fetuses, and skeletal defects of fetuses were used as parameters to identify the teratogenic effect. All data were analyzed using the ANOVA. All groups significantly differed between maternal and fetal body weights (p<0.05). The administration of rifampicin-pyrazinamide and propolis during pregnancy did not significantly affect the number of fetuses (p>0.05). The administration of propolis protects the fetus from skeletal abnormalities. While in the RP and IP groups, we can find resorption sites and haemorrhagic. This study may suggest the protective effects of propolis against rifampicin pyrazinamide-induced impaired pregnancy.
- Subjects
DRUG therapy for tuberculosis; ANTIBIOTICS; PYRAZINAMIDE; COMBINATION drug therapy; ABDOMINAL surgery; BODY weight; MUSCULOSKELETAL system abnormalities; DESCRIPTIVE statistics; TERATOGENIC agents; PROPOLIS; PLANT extracts; MICE; ANIMAL experimentation; ANALYSIS of variance; PREGNANCY complications; FETAL development; DATA analysis software; RIFAMPIN
- Publication
Journal of Complementary & Integrative Medicine, 2024, Vol 21, Issue 2, p197
- ISSN
1553-3840
- Publication type
Article
- DOI
10.1515/jcim-2023-0352