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- Title
GASTROINTESTINAL STROMAL TUMOUR (GIST): A RARE CAUSE OF INTESTINAL OBSTRUCTION IN NEONATE.
- Authors
J., Hayati; D., Stanislaus; R., Noraida; M., Fadhli; O., Nor Hayati; A. S., Mohd Ridzuan; Van Rostenberghe
- Abstract
Introduction: Gastrointestinal stromal tumour is very rare in newborns. A thorough literature search yielded less than 5 previous reports. Case Report: This is a report of a baby born with congenital GIST. The baby was born at term. Antenatal ultrasound showed features suggestive of duodenal obstruction. Postnatally the baby was not found to be dysmorphic, but there was abdominal distension confined to the upper region of the abdomen. Gastric aspirate was non bilious. Abdominal radiograph showed presence of 'double-bubble' air shadow suggestive of duodenal obstruction. The child was operated and intraoperative findings revealed an intraluminal mass in the first and second parts of the duodenum. Gastrojejunostomy and tumour debulking was performed. The diagnosis of GIST was made by histopathology and immunohistochemical studies of the tumour specimen. The tumour was positive for SMA and S 100 markers, but negative for CD117 (c-kit) and CD34. The tumour markers namely CEA, βHCG and αFP were normal. No evidence of metastasis was found. Postoperatively it was decided not to give chemotherapy to the child and at the age of 5 months, the child is asymptomatic and developing well. Discussion & Conclusion: This case illustrated a rare cause of duodenal obstruction in neonates
- Subjects
GASTROINTESTINAL stromal tumors; DUODENAL diseases; BOWEL obstructions; DIAGNOSTIC ultrasonic imaging; NEONATAL diseases
- Publication
Malaysian Journal of Medical Sciences, 2008, p179
- ISSN
1394-195X
- Publication type
Article