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- Title
Honey Ameliorates Hematological and Biochemical Changes Following Hemorrhage and Food Restriction.
- Authors
Saloom, Khelod Y.; Al-Waili, Noori S.; Al-Waili, Hamza; Al-Waili, Thia N.; Al-Waili, Ali N.; Al-Waili's, Mohummod Akmal
- Abstract
OBJECTIVE The objective was to assess (1) effects of various diets including total food restriction with 50% honey feeding (TFRH), total food restriction with 50% dextrose feeding (TFRD) or ad libitum (control group) commercial regular diet (DCRD), on hematological and biochemical variables, and (2) influence of the various diets on the same parameters after acute blood loss (ABL). MATERIALS AND METHODS Thirty Sprague Dawley albino rats were divided into 3 groups, 10 rats each. Group A was fed DCRD, Group B TFRD and Group C TFRH. After 8 days of feeding, rats were subjected to ABL (6 ml/kg) and blood investigations were performed. After ABL, same feedings were continued for further 8 days and the blood tests were repeated at day 8 post-bleeding. RESULTS TFRD compared to DCRD reduced hematological and biochemical variables. TFRH compared with TFRD caused greater reduction in fasting blood sugar (FBS), AST, ALT, and triacylglycerol (TG). ABL caused elevation of WBC, lymphocyte percent, fasting blood sugar (FBS), BUN, Alkaline phosphatase, TG, and a reduction in serum albumin, protein, cholesterol, AST, serum creatinine and hemoglobin (Hb). The differences were significant (p<0.05) for FBS, AST, alkaline phosphatase, serum albumin and protein. Significant reduction in FBS, WBC, BUN, AST, ALT, alkaline phosphatase, TG, and significant elevation of Hb and serum albumin were obtained after ABL in rats fed TFRH as compared to other two groups. TFRH increased serum albumin, serum protein, FBS, and caused lower reduction in Hb as compared to other groups. CONCLUSION Honey feeding during total food restriction significantly modifies and ameliorates biochemical and hematological changes observed after ABL. This will pave the way to use honey as a part of management of bleeding and during a food restriction regimen.
- Subjects
HONEY; HEMATOLOGY; HEMORRHAGE; DEXTROSE; DIET; RATS
- Publication
Malaysian Journal of Medical Sciences, 2007, Vol 14, Issue 1, p117
- ISSN
1394-195X
- Publication type
Article