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- Title
The evolution of chronic infection strategies in the α-proteobacteria.
- Authors
Batut, Jacques; Andersson, Siv G. E.; O'Callaghan, David
- Abstract
Many of the α-proteobacteria establish long-term, often chronic, interactions with higher eukaryotes. These interactions range from pericellular colonization through facultative intracellular multiplication to obligate intracellular lifestyles. A common feature in this wide range of interactions is modulation of host-cell proliferation, which sometimes leads to the formation of tumour-like structures in which the bacteria can grow. Comparative genome analyses reveal genome reduction by gene loss in the intracellular α-proteobacterial lineages, and genome expansion by gene duplication and horizontal gene transfer in the free-living species. In this review, we discuss α-proteobacterial genome evolution and highlight strategies and mechanisms used by these bacteria to infect and multiply in eukaryotic cells.
- Subjects
EUKARYOTIC cells; PATHOGENIC bacteria; BACTERIAL genetics; GENOMES; GENETIC transformation; CELL proliferation
- Publication
Nature Reviews Microbiology, 2004, Vol 2, Issue 12, p933
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro1044