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- Title
Predicting Harms and Benefits in Translational Trials: Ethics, Evidence, and Uncertainty.
- Authors
Kimmelman, Jonathan; London, Alex John
- Abstract
An essay is presented on the basis being used by investigators for predicting harms and benefits of translational trials. It mentions the problems with the use of animals in preclinical research as animals provide non reliable causal inference. It adds that the practice of evidential conservatism such as involving a particular agent with encouraging preclinical studies provides less reliability than compounds with information on relative success as a class.
- Subjects
CLINICAL trials; CLINICAL drug trials; LABORATORY animals; DRUG efficacy; INFERENCE (Logic)
- Publication
PLoS Medicine, 2011, Vol 8, Issue 3, p1
- ISSN
1549-1277
- Publication type
Essay
- DOI
10.1371/journal.pmed.1001010