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- Title
Righting the Wrongs: Structural Insights into Replicating Damaged DNA.
- Abstract
The article focuses on a study in which Olga Rechkoblit and colleagues examined the mechanisms by which Dpo4, a member of the Y-family polymerases, bypasses a DNA lesion. For their study they solved crystal structures of the polymerase at different stages of association with an oxoG-modified DNA template during its replication. They identified two amino acids in Dpo4 that play a critical role in forming hydrogen bonds formed through attraction of the positive charge of hydrogen with the nearby negatively charged phosphate group of the oxoG.
- Subjects
GENETIC research; DNA polymerases; DNA replication; DNA synthesis; HYDROGEN bonding; PHOSPHATES
- Publication
PLoS Biology, 2006, Vol 4, Issue 1, pe32
- ISSN
1544-9173
- Publication type
Article
- DOI
10.1371/journal.pbio.0040032