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- Title
Nationwide status of progestogen treatment to prevent spontaneous preterm birth: A questionnaire survey for childbirth healthcare facilities in Japan.
- Authors
Kawabata, Ikuno; Nagamatsu, Takeshi; Yoneda, Satoshi; Oi, Rie; Matsuda, Yoshio; Nakai, Akihito; Otsuki, Katsufumi
- Abstract
Aim: This study aimed to investigate the current status of progestogen treatment for pregnant women at a high risk for preterm birth (PTB) in childbirth healthcare facilities in Japan. Methods: A web‐based nationwide questionnaire survey regarding progestogen use for prevention of PTB was conducted among childbirth healthcare facilities from 2019 to 2021. Results: Valid responses were obtained from 528 facilities (25.2% of those surveyed), including 155 tertiary perinatal facilities (making up 92.3% of all tertiary perinatal care facilities). In the survey period, progestogen treatment was implemented in 207 facilities (39.2%) for PTB prevention. Regarding types of progestogens, 17α‐hydroxyprogesterone caproate was used in 170 facilities (82.1%), with a low dose (125 mg/week) administered in 62.9% of the facilities to comply with the regulations of the national health insurance system, although 250 mg/week is considered the best dose. Vaginal progesterone was used in 36 facilities (17.4%), although the cost of vaginal progesterone was not covered by health insurance. Of the facilities not administering progestogen treatment, approximately 40% expressed that vaginal progesterone would be their first choice for PTB prevention in daily practice if it would be covered by health insurance in the future. Conclusions: Due to the current regulations of the Japanese health insurance system, 17α‐hydroxyprogesterone caproate, rather than vaginal progesterone, was mainly used for PTB prevention. Despite global evidence supporting vaginal progesterone as the approach with the highest efficacy, only a limited number of facilities have utilized it due to the current drug use regulations in Japan.
- Subjects
JAPAN; HEALTH insurance laws; THERAPEUTIC use of progestational hormones; PROGESTERONE; PREMATURE infants; QUESTIONNAIRES; TERTIARY care; SURVEYS; DRUG efficacy; HEALTH facilities; INTRAVAGINAL administration; GOVERNMENT regulation; EVALUATION; PREGNANCY
- Publication
Journal of Obstetrics & Gynaecology Research, 2024, Vol 50, Issue 5, p873
- ISSN
1341-8076
- Publication type
Article
- DOI
10.1111/jog.15909