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- Title
Establishment of Experimental Murine Peritonitis Model with Hog Gastric Mucin for Carbapenem-Resistant Gram-Negative Bacteria.
- Authors
Jung Yeon Park; Chulmin Park; Hye-Sun Chun; Ji-Hyun Byun; Sung-Yeon Cho; Dong-Gun Lee
- Abstract
Animal models are essential to studies of infectious diseases. The use of mice to test bacterial infection has been extensively reported. However, methods applied to clinical isolates, particularly for carbapenem-resistant bacteria, must be tailored according to the infection models and bacteria used. In this study, we infected 6-week-old female BALB/c mice intraperitoneally with different strains of resistant bacteria plus 3% hog gastric mucin. This method was found to be efficient and readily applicable for investigation of carbapenem-resisant Gram-negative pathogens (e.g., Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii) detected in Korea.
- Subjects
PERITONITIS; GASTRIC mucosa; CARBAPENEMS; DRUG resistance in bacteria; INTRAPERITONEAL injections; THERAPEUTICS
- Publication
Infection & Chemotherapy, 2017, Vol 49, Issue 1, p57
- ISSN
2093-2340
- Publication type
Article
- DOI
10.3947/ic.2017.49.1.57