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Editorial: Therapeutic potential of the cannabinoid CB2 receptor.
Published in:
Frontiers in Pharmacology, 2022, v. 13, p. 01, doi. 10.3389/fphar.2022.1039564
By:
- Smoum, Reem;
- Grether, Uwe;
- Karsak, Meliha;
- Vernall, Andrea J.;
- Park, Frank;
- Hillard, Cecilia J.;
- Pacher, Pal
Publication type:
Article
Cannabinoid CB2 Receptors Modulate Microglia Function and Amyloid Dynamics in a Mouse Model of Alzheimer's Disease.
Published in:
Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.841766
By:
- Ruiz de Martín Esteban, Samuel;
- Benito-Cuesta, Irene;
- Terradillos, Itziar;
- Martínez-Relimpio, Ana M.;
- Arnanz, M. Andrea;
- Ruiz-Pérez, Gonzalo;
- Korn, Claudia;
- Raposo, Catarina;
- Sarott, Roman C.;
- Westphal, Matthias V.;
- Elezgarai, Izaskun;
- Carreira, Erick M.;
- Hillard, Cecilia J.;
- Grether, Uwe;
- Grandes, Pedro;
- Grande, M. Teresa;
- Romero, Julián
Publication type:
Article
Identifying opportunities for late-stage C-H alkylation with high-throughput experimentation and in silico reaction screening.
Published in:
Communications Chemistry, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42004-023-01047-5
By:
- Nippa, David F.;
- Atz, Kenneth;
- Müller, Alex T.;
- Wolfard, Jens;
- Isert, Clemens;
- Binder, Martin;
- Scheidegger, Oliver;
- Konrad, David B.;
- Grether, Uwe;
- Martin, Rainer E.;
- Schneider, Gisbert
Publication type:
Article
Prospective de novo drug design with deep interactome learning.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-47613-w
By:
- Atz, Kenneth;
- Cotos, Leandro;
- Isert, Clemens;
- Håkansson, Maria;
- Focht, Dorota;
- Hilleke, Mattis;
- Nippa, David F.;
- Iff, Michael;
- Ledergerber, Jann;
- Schiebroek, Carl C. G.;
- Romeo, Valentina;
- Hiss, Jan A.;
- Merk, Daniel;
- Schneider, Petra;
- Kuhn, Bernd;
- Grether, Uwe;
- Schneider, Gisbert
Publication type:
Article
A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-43606-3
By:
- Jiang, Ming;
- Huizenga, Mirjam C. W.;
- Wirt, Jonah L.;
- Paloczi, Janos;
- Amedi, Avand;
- van den Berg, Richard J. B. H. N.;
- Benz, Joerg;
- Collin, Ludovic;
- Deng, Hui;
- Di, Xinyu;
- Driever, Wouter F.;
- Florea, Bogdan I.;
- Grether, Uwe;
- Janssen, Antonius P. A.;
- Hankemeier, Thomas;
- Heitman, Laura H.;
- Lam, Tsang-Wai;
- Mohr, Florian;
- Pavlovic, Anto;
- Ruf, Iris
Publication type:
Article
An Oxidation-Labile Traceless Linker for Solid-Phase Synthesis.
Published in:
Angewandte Chemie International Edition, 1999, v. 38, n. 8, p. 1073, doi. 10.1002/(SICI)1521-3773(19990419)38:8<1073::AID-ANIE1073>3.0.CO;2-Y
By:
- Stieber, Frank;
- Grether, Uwe;
- Waldmann, Herbert
Publication type:
Article
NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS.
Published in:
EMBO Journal, 2018, v. 37, n. 16, p. 1, doi. 10.15252/embj.201798697
By:
- Ouali Alami, Najwa;
- Schurr, Christine;
- Olde Heuvel, Florian;
- Tang, Linyun;
- Li, Qian;
- Tasdogan, Alpaslan;
- Kimbara, Atsushi;
- Nettekoven, Matthias;
- Ottaviani, Giorgio;
- Raposo, Catarina;
- Röver, Stephan;
- Rogers‐Evans, Mark;
- Rothenhäusler, Benno;
- Ullmer, Christoph;
- Fingerle, Jürgen;
- Grether, Uwe;
- Knuesel, Irene;
- Boeckers, Tobias M.;
- Ludolph, Albert;
- Wirth, Thomas
Publication type:
Article
Preclinical Evaluation of the Reversible Monoacylglycerol Lipase PET Tracer (R)‐[11C]YH132: Application in Drug Development and Neurodegenerative Diseases.
Published in:
ChemBioChem, 2024, v. 25, n. 7, p. 1, doi. 10.1002/cbic.202300819
By:
- He, Yingfang;
- Delparente, Aro;
- Jie, Caitlin V. M. L;
- Keller, Claudia;
- Humm, Roland;
- Heer, Dominik;
- Collin, Ludovic;
- Schibli, Roger;
- Gobbi, Luca;
- Grether, Uwe;
- Mu, Linjing
Publication type:
Article
Mutually Rewarding Academia‐Industry Collaborations in the Field of Chemical Biology.
Published in:
ChemBioChem, 2023, v. 24, n. 11, p. 1, doi. 10.1002/cbic.202300121
By:
- Auberson, Yves P.;
- Grether, Uwe;
- Vauzeilles, Boris;
- Vázquez, Olalla
Publication type:
Article
EFMC: Trends in Medicinal Chemistry and Chemical Biology.
Published in:
ChemBioChem, 2023, v. 24, n. 7, p. 1, doi. 10.1002/cbic.202200690
By:
- Auberson, Yves P.;
- Arimondo, Paola B.;
- Duca, Maria;
- Essig, Sebastian;
- Grether, Uwe;
- Rufer, Arne C.;
- Sbardella, Gianluca;
- Schopfer, Ulrich;
- Torrens, Antoni;
- van der Stelt, Mario;
- Vauzeilles, Boris;
- Vázquez, Olalla;
- Zhang, Andrew X.
Publication type:
Article
Highly Selective, Amine‐Derived Cannabinoid Receptor 2 Probes.
Published in:
Chemistry - A European Journal, 2020, v. 26, n. 6, p. 1380, doi. 10.1002/chem.201904584
By:
- Westphal, Matthias V.;
- Sarott, Roman C.;
- Zirwes, Elisabeth A.;
- Osterwald, Anja;
- Guba, Wolfgang;
- Ullmer, Christoph;
- Grether, Uwe;
- Carreira, Erick M.
Publication type:
Article
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.
Published in:
Nature Communications, 2017, v. 8, n. 1, p. 13958, doi. 10.1038/ncomms13958
By:
- Soethoudt, Marjolein;
- Grether, Uwe;
- Fingerle, Jürgen;
- Grim, Travis W.;
- Fezza, Filomena;
- de Petrocellis, Luciano;
- Ullmer, Christoph;
- Rothenhäusler, Benno;
- Perret, Camille;
- van Gils, Noortje;
- Finlay, David;
- MacDonald, Christa;
- Chicca, Andrea;
- Gens, Marianela Dalghi;
- Stuart, Jordyn;
- de Vries, Henk;
- Mastrangelo, Nicolina;
- Xia, Lizi;
- Alachouzos, Georgios;
- Baggelaar, Marc P.
Publication type:
Article
Multistep Solid-Phase Synthesis of an Antibiotic and Receptor Tyrosine Kinase Inhibitors Using the Traceless Phenylhydrazide Linker.
Published in:
Chemistry - A European Journal, 2003, v. 9, n. 14, p. 3282, doi. 10.1002/chem.200304821
By:
- Frank Stieber;
- Uwe Grether;
- Ralph Mazitschek;
- Natascha Soric;
- Athanassios Giannis
Publication type:
Article
Development of the Traceless Phenylhydrazide Linker for Solid-Phase Synthesis.
Published in:
Chemistry - A European Journal, 2003, v. 9, n. 14, p. 3270, doi. 10.1002/chem.200304820
By:
- Frank Stieber;
- Uwe Grether;
- Herbert Waldmann
Publication type:
Article
An Enzyme-Labile Safety Catch Linker for Synthesis on a Soluble Polymeric Support.
Published in:
Chemistry - A European Journal, 2001, v. 7, n. 5, p. 959, doi. 10.1002/1521-3765(20010302)7:5<959::AID-CHEM959>3.0.CO;2-K
By:
- Grether, Uwe;
- Waldmann, Herbert
Publication type:
Article
Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors.
Published in:
Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1158091
By:
- Scott-Dennis, Morgan;
- Rafani, Fikri A.;
- Yicheng Yi;
- Perera, Themiya;
- Harwood, Clare R.;
- Wolfgang Guba;
- Rufer, Arne C.;
- Grether, Uwe;
- Veprintsev, Dmitry B.;
- Sykes, David A.
Publication type:
Article
A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature.
Published in:
PLoS ONE, 2022, v. 17, n. 9, p. 1, doi. 10.1371/journal.pone.0268590
By:
- Kemble, Alicia M.;
- Hornsperger, Benoit;
- Ruf, Iris;
- Richter, Hans;
- Benz, Jörg;
- Kuhn, Bernd;
- Heer, Dominik;
- Wittwer, Matthias;
- Engelhardt, Britta;
- Grether, Uwe;
- Collin, Ludovic
Publication type:
Article
An Enzyme-Labile Safety Catch Linker for Combinatorial Synthesis on a Soluble Polymeric Support.
Published in:
Angewandte Chemie International Edition, 2000, v. 39, n. 9, p. 1629, doi. 10.1002/(SICI)1521-3773(20000502)39:9<1629::AID-ANIE1629>3.0.CO;2-E
By:
- Grether, Uwe;
- Waldmann, Herbert
Publication type:
Article
Selective Cannabinoid 2 Receptor Agonists as Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis.
Published in:
Molecules, 2019, v. 24, n. 18, p. 3338, doi. 10.3390/molecules24183338
By:
- Porter, Richard Frederick;
- Szczesniak, Anna-Maria;
- Toguri, James Thomas;
- Gebremeskel, Simon;
- Johnston, Brent;
- Lehmann, Christian;
- Fingerle, Jürgen;
- Rothenhäusler, Benno;
- Perret, Camille;
- Rogers-Evans, Mark;
- Kimbara, Atsushi;
- Nettekoven, Matthias;
- Guba, Wolfgang;
- Grether, Uwe;
- Ullmer, Christoph;
- Kelly, Melanie E. M.;
- Nikas, Spyros P.
Publication type:
Article
Reverse Design toward Optimized Labeled Chemical Probes - Examples from the Endocannabinoid System.
Published in:
Chimia, 2022, v. 76, n. 5, p. 425, doi. 10.2533/chimia.2022.425
By:
- Guberman, Mónica;
- Kosar, Miroslav;
- Omran, Anahid;
- Carreira, Erick M.;
- Nazaré, Marc;
- Grether, Uwe
Publication type:
Article
Late-Stage Functionalization and its Impact on Modern Drug Discovery.
Published in:
Chimia, 2022, v. 76, n. 3, p. 258, doi. 10.2533/chimia.2022.258
By:
- Nippa, David F.;
- Hohler, Remo;
- Stepan, Antonia F.;
- Grether, Uwe;
- Konrad, David B.;
- Martin, Rainer E.
Publication type:
Article
Inside Cover: Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases (ChemMedChem 2/2016).
Published in:
ChemMedChem, 2016, v. 11, n. 2, p. 147, doi. 10.1002/cmdc.201500604
By:
- Nettekoven, Matthias;
- Adam, Jean-Michel;
- Bendels, Stefanie;
- Bissantz, Catarina;
- Fingerle, Jürgen;
- Grether, Uwe;
- Grüner, Sabine;
- Guba, Wolfgang;
- Kimbara, Atsushi;
- Ottaviani, Giorgio;
- Püllmann, Bernd;
- Rogers-Evans, Mark;
- Röver, Stephan;
- Rothenhäusler, Benno;
- Schmitt, Sebastien;
- Schuler, Franz;
- Schulz-Gasch, Tanja;
- Ullmer, Christoph
Publication type:
Article
Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases.
Published in:
ChemMedChem, 2016, v. 11, n. 2, p. 179, doi. 10.1002/cmdc.201500218
By:
- Nettekoven, Matthias;
- Adam, Jean-Michel;
- Bendels, Stefanie;
- Bissantz, Catarina;
- Fingerle, Jürgen;
- Grether, Uwe;
- Grüner, Sabine;
- Guba, Wolfgang;
- Kimbara, Atsushi;
- Ottaviani, Giorgio;
- Püllmann, Bernd;
- Rogers-Evans, Mark;
- Röver, Stephan;
- Rothenhäusler, Benno;
- Schmitt, Sebastien;
- Schuler, Franz;
- Schulz-Gasch, Tanja;
- Ullmer, Christoph
Publication type:
Article
Comparative Molecular Profiling of the PPARα/γ Activator Aleglitazar: PPAR Selectivity, Activity and Interaction with Cofactors.
Published in:
ChemMedChem, 2012, v. 7, n. 6, p. 1101, doi. 10.1002/cmdc.201100598
By:
- Dietz, Michel;
- Mohr, Peter;
- Kuhn, Bernd;
- Maerki, Hans Peter;
- Hartman, Peter;
- Ruf, Armin;
- Benz, Jörg;
- Grether, Uwe;
- Wright, Matthew B.
Publication type:
Article
New Insights on the Mechanism of PPAR-targeted Drugs.
Published in:
ChemMedChem, 2010, v. 5, n. 12, p. 1973, doi. 10.1002/cmdc.201000446
By:
- Grether, Uwe;
- Klaus, Werner;
- Kuhn, Bernd;
- Maerki, Hans Peter;
- Mohr, Peter;
- Wright, Matthew B.
Publication type:
Article
Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists.
Published in:
ChemMedChem, 2009, v. 4, n. 6, p. 951, doi. 10.1002/cmdc.200800425
By:
- Grether, Uwe;
- Bénardeau, Agnes;
- Benz, Jörg;
- Binggeli, Alfred;
- Blum, Denise;
- Hilpert, Hans;
- Kuhn, Bernd;
- Märki, Hans Peter;
- Meyer, Markus;
- Mohr, Peter;
- Püntener, Kurt;
- Raab, Susanne;
- Ruf, Armin;
- Schlatter, Daniel
Publication type:
Article
Inside Cover: Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists (ChemMedChem 6/2009).
Published in:
ChemMedChem, 2009, v. 4, n. 6, p. 886, doi. 10.1002/cmdc.200990027
By:
- Grether, Uwe;
- Bénardeau, Agnes;
- Benz, Jörg;
- Binggeli, Alfred;
- Blum, Denise;
- Hilpert, Hans;
- Kuhn, Bernd;
- Märki, Hans Peter;
- Meyer, Markus;
- Mohr, Peter;
- Püntener, Kurt;
- Raab, Susanne;
- Ruf, Armin;
- Schlatter, Daniel
Publication type:
Article
RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models.
Published in:
Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1426446
By:
- Grether, Uwe;
- Foxton, Richard H.;
- Gruener, Sabine;
- Korn, Claudia;
- Kimbara, Atsushi;
- Osterwald, Anja;
- Zirwes, Elisabeth;
- Uhles, Sabine;
- Thoele, Janina;
- Colé, Nadine;
- Rogers-Evans, Mark;
- Röver, Stephan;
- Nettekoven, Matthias;
- Martin, Rainer E.;
- Adam, Jean-Michel;
- Fingerle, Jürgen;
- Bissantz, Caterina;
- Guba, Wolfgang;
- Alker, André;
- Szczesniak, Anna M.
Publication type:
Article

Found: 28

Editorial: Therapeutic potential of the cannabinoid CB2 receptor.

Cannabinoid CB<sub>2</sub> Receptors Modulate Microglia Function and Amyloid Dynamics in a Mouse Model of Alzheimer's Disease.

Identifying opportunities for late-stage C-H alkylation with high-throughput experimentation and in silico reaction screening.

Prospective de novo drug design with deep interactome learning.

A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence.

An Oxidation-Labile Traceless Linker for Solid-Phase Synthesis.

NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS.

Preclinical Evaluation of the Reversible Monoacylglycerol Lipase PET Tracer (R)‐[<sup>11</sup>C]YH132: Application in Drug Development and Neurodegenerative Diseases.

Mutually Rewarding Academia‐Industry Collaborations in the Field of Chemical Biology.

EFMC: Trends in Medicinal Chemistry and Chemical Biology.

Highly Selective, Amine‐Derived Cannabinoid Receptor 2 Probes.

Cannabinoid CB<sub>2</sub> receptor ligand profiling reveals biased signalling and off-target activity.

Multistep Solid-Phase Synthesis of an Antibiotic and Receptor Tyrosine Kinase Inhibitors Using the Traceless Phenylhydrazide Linker.

Development of the Traceless Phenylhydrazide Linker for Solid-Phase Synthesis.

An Enzyme-Labile Safety Catch Linker for Synthesis on a Soluble Polymeric Support.

Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors.

A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature.

An Enzyme-Labile Safety Catch Linker for Combinatorial Synthesis on a Soluble Polymeric Support.

Selective Cannabinoid 2 Receptor Agonists as Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis.

Reverse Design toward Optimized Labeled Chemical Probes - Examples from the Endocannabinoid System.

Late-Stage Functionalization and its Impact on Modern Drug Discovery.

Inside Cover: Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases (ChemMedChem 2/2016).

Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases.

Comparative Molecular Profiling of the PPARα/γ Activator Aleglitazar: PPAR Selectivity, Activity and Interaction with Cofactors.

New Insights on the Mechanism of PPAR-targeted Drugs.

Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists.

Inside Cover: Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists (ChemMedChem 6/2009).

RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models.