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- Title
High drug loading capacity of UiO-69 metal–organic framework with linkers 2,6-naphthalenedicarboxylic acid with carboplatin.
- Authors
Al-Omoush, M. K.; Polozhentsev, O. E.; Soldatov, A. V.
- Abstract
The encapsulation of therapeutic drugs in drug delivery containers as metal–organic frameworks (MOFs) has the potential to enhance the effectiveness of chemotherapy. The drug loading capacity of the nanoscale UiO-69 MOF has been investigated by encapsulating carboplatin (CarboPt), a therapeutic agent, within the MOF structure. A UiO-69@CarboPt nanocomposite was synthesized using a one-pot technique, in which carboplatin was encapsulated within the UiO-69 MOF structure. Advanced analytical techniques, such as X-ray diffraction (XRD), X-ray fluorescence (XRF), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), Raman spectroscopy, and UV–Vis spectroscopy, were employed to examine the structural characteristics, morphology, and atomic structure of the nanocomposite. The study observed that the nanoscale UiO-69 MOF with 2,6-naphthalenedicarboxylic acid as an organic linker had a significantly increased loading capacity due to linker lengthening, as well as the MOF's unique morphology, contributed to this increased drug loading capacity. Drug release studies in phosphate-buffered saline (PBS) at 37 °C demonstrate a controlled release profile for UiO-69@Pt4, with 30% release after 3 h and 76% after 24 h. The carboplatin-encapsulated UiO-69 MOF nanocomposite holds potential for biomedical applications, particularly in drug delivery and chemotherapy.
- Subjects
CARBOPLATIN; METAL-organic frameworks; X-ray emission spectroscopy; X-ray fluorescence; TRANSMISSION electron microscopy; INFRARED spectroscopy; ULTRAVIOLET-visible spectroscopy
- Publication
Journal of Nanoparticle Research, 2024, Vol 26, Issue 1, p1
- ISSN
1388-0764
- Publication type
Article
- DOI
10.1007/s11051-023-05912-1