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- Title
The sequence organization of the long arm pseudoautosomal region of the human sex chromosomes.
- Authors
Kvaløy, K.; Galvagni, F.; Brown, W.R.A.
- Abstract
We have analysed the sequence organization of the pseudoautosomal region at the telomeres of the long arms of the human sex chromosomes and shown that It is 320 kb long. A LINE sequence Is present on both the X and Y chromosomes immediately adjacent to the breakpoint in homology suggesting that the homology arose as a result of an ectopic recombination event mediated by LINE sequences originally present in non-homologous stretches of X and Y chromosomal DNA. This led to the translocatlon of sequences from the X chromosome telomere onto the Y chromosome and created a new pseudoautosomal region.
- Publication
Human Molecular Genetics, 1994, Vol 3, Issue 5, p771
- ISSN
0964-6906
- Publication type
Article