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- Title
In Vitro Toxicity Study of a Porous Iron(III) Metal‒Organic Framework.
- Authors
Chen, Gongsen; Leng, Xin; Luo, Juyuan; You, Longtai; Qu, Changhai; Dong, Xiaoxv; Huang, Hongliang; Yin, Xingbin; Ni, Jian
- Abstract
A MIL series metal‒organic framework (MOF), MIL-100(Fe), was successfully synthesized at the nanoscale and fully characterized by TEM, TGA, XRD, FTIR, DLS, and BET. A toxicological assessment was performed using two different cell lines: human normal liver cells (HL-7702) and hepatocellular carcinoma (HepG2). In vitro cytotoxicity of MIL-100(Fe) was evaluated by the MTT assay, LDH releasing rate assay, DAPI staining, and annexin V/PI double staining assay. The safe dose of MIL-100(Fe) was 80 μg/mL. It exhibited good biocompatibility, low cytotoxicity, and high cell survival rate (HL-7702 cells' viability >85.97%, HepG2 cells' viability >91.20%). Therefore, MIL-100(Fe) has a potential application as a drug carrier.
- Subjects
CYTOPROTECTION; REJUVENESCENCE (Botany); REGENERATION (Biology); CYTOLOGY; EMBRYOLOGY
- Publication
Molecules, 2019, Vol 24, Issue 7, p1211
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24071211