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- Title
Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives.
- Authors
Rioton, Sarah; Pardo, Domingo Gomez; Cossy, Janine
- Abstract
A comprehensive survey of pathways leading to the generation of α-trifluoromethyl monocyclic piperidinic derivatives is provided (65 references). These compounds have been synthesized either from 6-membered rings e.g., pipecolic acid or lactam derivatives by introduction a trifluoromethyl group, from pyridine or pyridinone derivatives by reduction, and from 5-membered rings e.g., prolinol derivatives by ring expansion, from linear amines by cyclization or from dienes/dienophiles by [4 + 2]-cycloaddition.
- Subjects
TRIFLUOROMETHYL compounds synthesis; CHEMICAL derivatives; CHEMICAL reduction; PYRIDONE derivatives; RING formation (Chemistry)
- Publication
Molecules, 2017, Vol 22, Issue 3, p483
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22030483