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- Title
Answer to the Letter to the Editor of MJ Bolland, et al. concerning "Characteristics of baseline frequency data in spinal RCTs do not suggest widespread non-random allocation" by MMS Levayer, et al. (Eur Spine J [2023]32:3009–3014).
- Authors
Levayer, Manon Malia Sydney; Chew, Gem Rui Ping; Sheldrick, Kyle Alexander; Diwan, Ashish Dhar
- Abstract
The authors of the letter express gratitude for the interest in their research and provide four comments in response. Firstly, their paper focused on investigating whether research data fabrication was common in spine research, specifically examining signs of implausible similarity or difference in baseline data between arms. They did not draw conclusions about other issues such as errors in manuscripts or poor reporting practices. Secondly, they were unable to replicate many published p-values for baseline data, which raises concerns about errors in reporting spine trial baseline data. Thirdly, they caution against interpreting the higher proportion of extreme p-values in studies with a large number of variables, suggesting that the assumption of zero auto-correlation becomes more tenuous as the number of variables increases. Finally, they discuss the evolution of fraud detection in science and acknowledge the possibility of problematic papers being identified in the future using new tools. The authors express gratitude for the interest in their work and the valuable contribution to integrity in spinal research.
- Subjects
SPINE; DOPING in sports; FRAUD investigation; EXTREME value theory
- Publication
European Spine Journal, 2024, Vol 33, Issue 4, p1705
- ISSN
0940-6719
- Publication type
Article
- DOI
10.1007/s00586-024-08169-x