We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth.
- Authors
Jie Kang; Chao Liu; Hongqing Wang; Baoming Li; Chao Li; Ruoyun Chen; Ailin Liu
- Abstract
One new flavonoid named (2R,3R)-7-O-galloylplumbocatechin A (1) and three known flavonoids, (-)-5,3',4',5'-tetrahydroxyflavan-7-gallate (2), (+)-3,5,3',4',5'-penta-hydroxyflavan-7-gallate (3), and (-)-7,4'-di-O-galloyltricetiflavan (4), were isolated from Pithecellobium clypearia Benth. Their structures were elucidated based on spectroscopic analysis, including homonuclear and heteronuclear correlation NMR (HSQC and HMBC) experiments. In vitro assays, compounds 1 and 2 showed moderate inhibitory effects against influenza H1N1 virus neuraminidase (NA). Compounds 1-4 were all found to inhibit the expression of proinflammatory cytokines IL-6 or MCP-1 induced by influenza H1N1 virus in human A549 lung carcinoma cells.
- Subjects
FLAVONOIDS spectra; BLACKBEAD (Plant); NUCLEAR magnetic resonance spectroscopy; COHERENCE (Optics); INFLUENZA A virus, H1N1 subtype; NEURAMINIDASE; CANCER cells
- Publication
Molecules, 2014, Vol 19, Issue 4, p4479
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules19044479