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- Title
Design, Synthesis and Antifibrotic Activities of Carbohydrate- Modified 1-(Substituted aryl)-5-trifluoromethyl-2(1H) Pyridones.
- Authors
Qinghua Lou; Xiangbao Meng; Zhiqi Lao; Lingling Xuan; Jinye Bai; Qi Hou; Gaoyun Hu; Renna Luo; Lijian Tao; Zhongjun Li
- Abstract
Pirfenidone, a pyridone compound, is an effective and novel antifibrotic agent. In this article, we describe the design, synthesis and activity evaluation of novel antifibrotic agents, 1-(substituted aryl)-5-trifluoromethyl-2(1H) pyridones modified with carbohydrate. Most of the title compounds exhibited comparable or better inhibitory activity than fluorofenidone. Notably, compound 19a demonstrated the highest cell-based inhibitory activity against NIH 3T3 (IC50 = 0.17 mM).
- Subjects
PYRIDONE; HYDROXYPYRIDONES; MIMOSINE; RILOPIROX; TRIFLUOROMETHYL compounds
- Publication
Molecules, 2012, Vol 17, Issue 1, p884
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules17010884