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- Title
Immunocytochemical Staining of Proliferating Cells in Endoscopically Biopsied Tissues of Gastric Carcinomas with Monoclonal Antibody Ki-67.
- Authors
Yonemura, Yutaka; Kimura, Hironobu; Ooyama, Shigekazu; Kamata, Tom; Yamaguchi, Akio; Matsumoto, Hisashi; Ninomiya, Itasu; Miyazaki, Itsuo
- Abstract
The growth fractions in endoscopically biopsied materials from 121 patients with gastric carcinomas were determined by immunohistochemical staining with the monoclonal antibody Ki-67 and the results correlated with the histopathologic findings and clinical outcome. The Ki-67 labeling rates ranged from 4.6 to 52% (mean: 22%). A significant correlation was found between Ki-67 labeling rates of biopsied materials and those of resected specimens. The tumors showing Ki-67 labeling rates of greater than 22% are more likely to have lymph node metastasis, lymphatic invasion or serosal invasion than those with the rates below 22%. In addition, Ki-67 labeling rates were closely associated with prognosis. Tumors with high Ki-67 labeling rates (greater than 22%) were related to poor prognosis, whereas those with low Ki-67 labeling rates were associated with favorable prognosis. The immunohistochemical staining of proliferating cells in endoscopically biopsied specimens of gastric carcinomas using the Ki-67 monoclonal antibody may be useful in assessing prognosis in carcinoma of the stomach. Copyright © 1991 S. Karger AG, Basel
- Publication
Oncology, 1991, Vol 48, Issue 2, p162
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000226918