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- Title
Proton radiotherapy for malignant melanoma of the skin.
- Authors
Umebayashi, Y.; Uyeno, K.; Tsujii, H.; Otsuka, F.
- Abstract
<bold>Background: </bold>Malignant melanoma, a tumor with reduced radiosensitivity, has been suggested to be overcome by a high-dose fractionation radiotherapy. The proton beam presents physical characteristics that enable such high-dose irradiation.<bold>Objective: </bold>Our aim is to answer whether or not the proton beam can provide useful treatment for cutaneous melanoma.<bold>Methods: </bold>Five primary melanomas (4 acral lentiginous and 1 superficial spreading type) and 3 metastatic lymph nodes of 3 different patients were irradiated using the proton beam with a total dose of around 100 Gy fractionated into single doses of approximately 10 Gy.<bold>Results: </bold>All the macular lesions and a tumor lesion of primary melanoma disappeared completely, and other tumor lesions regressed by 80-90%. The 3 metastatic lymph nodes also regressed by 50-90%. No severe radiation-related complication occurred.<bold>Conclusion: </bold>Proton radiotherapy may prove to be a useful therapeutic modality for the management of cutaneous malignant melanoma.
- Publication
Dermatology (10188665), 1995, Vol 190, Issue 3, p210
- ISSN
1018-8665
- Publication type
journal article
- DOI
10.1159/000246687